Binding to double-stranded hemi-methylated DNA at replication foci (one strand methylated, while the other strand is unmethylated). Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks.

Binding to double-stranded DNA.

Catalysis of the activation of the small ubiquitin-related modifier FAT10, through the formation of an ATP-dependent high-energy thiolester bond.

Catalysis of the initiation of the NEDD8 (RUB1) conjugation cascade.

Catalysis of the activation of the small ubiquitin-related modifier ISG15, through the formation of an ATP-dependent high-energy thiolester bond.

An isopeptidase activity that cleaves ubiquitin or ubiquitin-like proteins (ULP; e.g. ATG8, ISG15, NEDD8, SUMO) from target proteins.

Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.

An isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated.

A thiol-dependent isopeptidase activity that cleaves ISG15 from a target protein to which it is conjugated.

Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.

Any process that reduces the size of an imaginal disc-derived wing.

A thiol-dependent isopeptidase activity that cleaves APG8 from a target protein to which it is conjugated.

Catalytic activity that acts to modify a protein.

Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.

The process by which the cargo protein is released into the peroxisomal matrix, following translocation across the membrane.

The disaggregation of a protein-containing macromolecular complex into its constituent components.

Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y --> Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages.

Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y --> Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages.

Binding to a Type I interleukin-1 receptor.

Binding to a Type II interleukin-1 receptor.