The pathway by which a ribonucleotide is removed from DNA and replaced by a deoxyribonucleotide. The ribonucleotide is incised by RNase H2, and further excised by an endonuclease. The resulting 1 nt gap is then repaired by DNA polymerase and DNA ligase.

A mismatch repair process that corrects errors introduced that ensures the accuracy of DNA replication.

An enzyme complex that catalyzes the ligation of phenylalanine to tRNA(Phe), forming L-phenylalanyl-tRNA(Phe).

The process in which a relatively unspecialized cell acquires specialized features of an anterior lateral line neuromast hair cell. Neuromast hair cells are the sensory receptors of the neuromast and are located in a portion of the neuromast called the sensory strip. Each hair cell of the neuromast is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. There are approximately seven hair cells within each neuromast, with each hair cell innervated by afferent and efferent neurons.

The process in which a relatively unspecialized cell acquires specialized features of a neuromast hair cell. Hair cells are the sensory receptors of the neuromast and are located in a portion of the neuromast called the sensory strip. Each hair cell of the neuromast is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. There are approximately seven hair cells within each neuromast, with each hair cell innervated by afferent and efferent neurons.

OBSOLETE. A process in which a protein is transported to, or maintained in, a location within a photoreceptor outer segment, which is a portion of a modified sensory cilium.

The process in which a relatively unspecialized cell acquires specialized features of a neuron of the anterior lateral line ganglion.

The process in which a relatively unspecialized cell acquires specialized features of a lateral line ganglion neuron.

An RNA interference where the silencing signal spreads 5' along the target mRNA, outside of the initial target sequence. Typically involves the formation of secondary siRNAs formed when the initial mRNA target sequence functions as a template for 5' to 3' synthesis of new dsRNA.

An RNA interference where the silencing signal spreads along the target mRNA in a 5' or 3' direction, outside of the initial target sequence.

The process whose specific outcome is the progression of the anterior lateral line nerve over time, form its formation to the mature structure. The anterior lateral line nerve contains efferent axons that innervate hair cells of the ALL and afferent axons that project to an octavolateralis column in the hindbrain. The octavolateralis column consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus.

An RNA interference where the silencing signal spreads 3' along the target mRNA, outside of the initial target sequence. Typically involves the formation of secondary siRNAs formed when the initial mRNA target sequence functions as a template for 5' to 3' synthesis of new dsRNA.

The process in which a relatively unspecialized cell acquires specialized features of an anterior lateral line neuromast support cell. Support cells are non-sensory cells of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; they are surrounded by mantle cells.

The process in which a relatively unspecialized cell acquires specialized features of a neuromast support cell. Support cells are non-sensory cells of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; they are surrounded by mantle cells.

Nuclear transcriptional repressor complex that is capable of negatively regulating CLOCK-BMAL-dependent transactivation of genes in a delayed negative feedback manner which generates circadian rhythms.

A protein complex that possesses activity that prevents or downregulates transcription.

The process whose specific outcome is the progression of the anterior lateral line ganglion over time, from its formation to the mature structure. The anterior lateral line ganglion develops from cranial ectodermal placodes situated between the eye and ear.

Transcription factor complex which interacts with E-box regulatory elements in target genes, including Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2), to activate their transcription during the daytime. The CRY-PER complexes inhibit CLOCK-BMAL1-driven transcription in a negative feedback loop to generate circadian rhythms.

The chemical reactions and pathways resulting in the formation of piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.